Key findings from a new study reveal how ultraviolet (UV) radiation weakens the body’s natural defenses against skin cancer, reinforcing the importance of sun protection.
Researchers have pinpointed a biological mechanism where prolonged UV exposure reduces a protective protein called YTHDF2, which normally prevents skin cells from becoming cancerous. This decline makes skin more vulnerable to inflammation, accelerating cancer development. The study, published in a leading scientific journal, also highlights how UV radiation disrupts RNA molecules, further amplifying inflammatory responses linked to cancer.
Зміст
How UV Exposure Weakens Skin’s Defenses
The research, conducted on both human and mouse cells, demonstrates that UV exposure doesn’t just damage DNA (as previously understood). It also compromises RNA, triggering a cascade of inflammation that overrides the body’s natural cancer prevention systems. When YTHDF2 levels drop, UV-induced inflammation worsens, creating a vicious cycle that increases the risk of skin cancer.
“We know that UV light exposure from the sun is associated with the development of skin cancers. This new research further explains the process.” – Joshua Zeichner, MD, Mount Sinai Hospital
This discovery suggests that future prevention strategies could focus on reversing the impact of UV damage on RNA, potentially offering new treatments to combat skin cancer.
Why This Matters
Skin cancer is one of the most common cancers worldwide, with UV exposure being a primary risk factor. Understanding exactly how UV radiation triggers cancer is crucial for developing better prevention methods. This study moves beyond the simple “avoid the sun” advice by identifying specific molecular targets that could be manipulated to protect skin cells.
Balancing Sun Exposure and Protection
While excessive sun exposure is dangerous, some sunlight is beneficial for vitamin D production and mood regulation. Experts emphasize moderation.
“Balance and moderation are key,” says Vishal Patel, MD, GW School of Medicine & Health Sciences. “We can protect ourselves from the sun in the form of sunscreen use, sun protective clothing and hats, and sitting in the shade when possible.”
What’s Next?
Researchers plan to investigate the interactions between RNA and proteins involved in inflammation, hoping to develop targeted treatments. This discovery could pave the way for new therapies that not only prevent skin cancer but also reverse its early stages.
The study reinforces the importance of diligent sun protection while also opening doors to more effective prevention strategies.
